המאמר האחרון בנושא שפורסם השנה:
Reproductive BioMedicine Online (2011) 23, 361– 362
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Quantifying the effectiveness and cost-efficiency
of food supplementation with antioxidants for
male infertility
Frank Comhaire a,*, Wim Decleer b
a Ghent University, Brakelmeersstraat, 18, B 9830 Sint Martens-Latem, Belgium; b Fertility-Belgium,
Weststraat, 16-18, B 9880 Aalter, Belgium
Abstract In male infertility, complementary treatment with antioxidant-containing food supplements quadruples the spontaneous
pregnancy rate and reduces the cost per pregnancy by 60%. RBMOnline
Discussion
One-fifth of all placebo-controlled trials of oral antioxidant
treatment have failed to reveal any benefit (Ross et al.,
2010). This may be due to the use of an inadequate dose
and/or type of oral antioxidant. For example, Rolf et al.
(1999) have given a high dose of ascorbic acid
(1000 mg/day) which may exert a pro-oxidative rather than
an anti-oxidative effect, particularly among men with the
haptoglobin type 2–2 (Langlois et al., 1997). Similarly a high
dose (800 mg) of the vitamin E analogue tocopherol succinate
was found to adversely effect the gap-junctional intercellular
communication (Chaumontet et al., 2008), which is
of pivotal importance for spermatogenesis.
Antioxidant treatment should be applied in the correct
dosage and the judicious combination of several food supplements
is probably preferable to optimize different
aspects of cell integrity and cell function (Comhaire, 2010).
Since conclusions on the effectiveness of a treatment
that are based on either clinical pregnancy or live birth as
endpoints are comparable (Clarke et al., 2010), the present
data underscore the effectiveness of oral antioxidant supplementation
in male infertility, quadrupling the probability
of spontaneous pregnancy within 3 months, and reducing
the cost per pregnancy by 60%.