תופעות לוואי רטלין תגובה לתגובה

תודה רבה לך, על תשובתך, כאם בהחלט מרגיע, פשוט האתר המדווח נראה רציני, אם אינני טועה, זהו אתר איגוד התרופות של האיחוד הארופי.
הדברים אומנם גם שם כתובים עם הרבההסתייגות, אבל אלה הם הדברים , ומעניין על מה לדעתך הם מסתמכים? ציטוט מן האתר:
2.5 Leukaemia
Recent findings from a case-control study have indicated a potentially increased risk of lymphocytic leukaemia with methylphenidate, which the MAHs were required to further evaluate. The MAHs submitted data supporting the position that there is no preclinical or clinical evidence for a significant carcinogenic risk associated with methylphenidate. Methylphenidate may have some activity as a non-genotoxic carcinogen in mouse liver; however, the limited human analyses do not suggest that this activity is reproduced in humans exposed to therapeutic doses.
The recently published retrospective case control review of prescription records for more than 35,000 patients did not indicate either a moderate or a strong association between methylphenidate use and cancer risk in children for any of 18 defined cancer sites. This only study raises a potential signal of risk of leukaemia with methylphenidate use, despite the limitations of the findings, as discussed by the authors and the MAHs. A currently ongoing cytogenicity study may give responses when finalised. The MAHs will submit the resukts for assessment when available. The CHMP concluded that the current initiatives to further evaluate any risk of carcinogenicity with methylphenidate are endorsed.