כאבים

התופעה אפשרית אחרי הזרעה-זרע מכיל חומר הקרוי פרוסטגלנדין שיכול לעורר התכווצויות ברחם וגם יכול להשפיע על כלי הדם בשד ומכאן הלחץ בפטמות-להלן מאמר המצביע על תפקיד הפרוסטגלנדינים בקביעת בוונוס של כלי הדם בשד:
The local differential effect of prostacyclin, prostaglandin E2 and prostaglandin F2 alpha on mammary blood flow of lactating goats.

AuthorsNielsen MO, et al. Show all Journal
J Endocrinol. 1995 Jun;145(3):585-91.

Affiliation
Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.

Abstract
Mammary blood flow (MBF) and milk yield are closely related in dairy ruminants, but little is known about the regulation of MBF in vivo. The local effects on MBF of injections or continuous infusions into the mammary artery of prostaglandins (PG) or indomethacin (an inhibitor of prostaglandins) respectively, were investigated in surgically prepared conscious goats. Prostacyclin (PGI2) was found to be a potent stimulator of MBF which increased linearly over the dose range 50-1000 ng. PGE2 was almost as potent as PGI2 at low doses, but tachyphylaxis occurred at doses at and above 100 ng. The response to repeated injections of PGE2 quickly declined depending on the dose. PGF2 alpha had no effect on MBF. During infusion of indomethacin into the mammary artery MBF was reduced markedly, showing that endogenous mammary prostaglandins are involved in the regulation of vasodilatation. The results indicate that PGI2 (and to a lesser extent PGE2) has an important role in the local regulation of vascular tone in the mammary gland.