זייבן וטיפולי IVF

לגבי הטיפול עצמו - אין נתונים ברורים.
לגבי הריון:
Of 322 outcomes involving bupropion exposure in the first trimester there were 261 live births without birth defects, 40 spontaneous pregnancy losses, 11 induced abortions, 1 induced abortion with evidence of Down syndrome on prenatal testing, and 9 infants born alive with birth defects.

The defects in infants born alive included one infant with bilateral club feet, one infant with Klinefelter's syndrome (no physical abnormalities), and 7 infants with heart defects (1 abnormal aortic valve thickening with mild aortic insufficiency, 1 ventricular septal defect, 1 trivial pulmonic stenosis with atrial septal defect, 1 coarctation with ventricular septal defect, 1 thickened heart muscle, 1 pulmonary stenosis, and 1 coarctation of the aorta).

The observed proportion of birth defects in pregnancies with prenatal exposure to bupropion in the first trimester was 3.7%.

The registry's Advisory Committee noted the increased number of prospective reports of defects involving the heart and great vessels. Given the small sample size and the potential bias from the large percentage of cases lost to follow up an accurate assessment of a potential effect of bupropion on the developing cardiovascular system could not be made. To further evaluate the possible association of bupropion with cardiovascular defects The Committee plans to conduct a retrospective cohort study entitled "Bupropion in Pregnancy and the Risk of Cardiovascular and Overall Major Congenital Malformations". (2).

וכן

ZYBAN is not recommended for women who are pregnant or breast-feeding. Women should notify their doctor if they become pregnant or intend to become pregnant while taking ZYBAN. Post-marketing reports indicate that some newborns whose mother took an SSRI (Selective Serotonin Reuptake Inhibitor) or other newer anti-depressant, such as ZYBAN, during pregnancy have developed complications at birth requiring prolonged hospitalization, breathing support and tube feeding. Reported symptoms include: feeding and/or breathing difficulties, seizures, tense or overly relaxed muscles, jitteriness and constant crying. In most cases, the newer anti-depressant was taken during the third trimester of pregnancy. These symptoms are consistent with either a direct adverse effect of the anti-depressant on the baby, or possibly a discontinuation syndrome caused by sudden withdrawal from the drug. These symptoms normally resolve over time.