שאלה לגבי האיקאקלמין

האם יכול להיות מצב שבו נקלטים להריון ועדיין יש דימום חודשי כמו המחזור? ואם שותים איקאקלמין כי לא יודעים שנקלטים האם יש נזק? מה יכול לקרות? תודה

כן, יתכן הריון עם דימום.
אם יש אפשרות להריון - עדיף לבצע בדיקת דם לבטא לפני תחילת טיפול באיקקלומין.
ראי
Clomiphene is used to induce ovulation and is contraindicated after conception has occurred. Multiple pregnancies, most often twins, may be a complication of ovulation induction with clomiphene (1).

Shepard reviewed five animal reproduction studies involving the use of clomiphene in mice, rats, and monkeys (2). Hydramnios, cataracts, dose-related fetal mortality, and multiple abnormalities of the genital tract were observed in fetal mice and rats, but no congenital anomalies resulted after exposure of monkeys during the embryonic period. In mice, preovulatory administration of clomiphene produced a decrease in implantation rates, and growth retardation and an increased incidence of exencephaly in surviving fetuses (3). The decreased rate of implantation and growth retardation, which were most pronounced when the drug was given immediately before ovulation, apparently were caused by impairment of uterine function, rather than by a direct effect on the embryo itself (3).

Several case reports of neural tube defects have been reported after stimulating ovulation with clomiphene (4,5,6,7 and 8). However, an association between the drug and these defects has not been established (9,10,11,12,13,14,15,16 and 17). In one review, the percentage of congenital anomalies after clomiphene use was no greater than in the normal population (9). Similarly, another study involving 1,034 pregnancies after clomiphene-induced ovulation found no association with the incidence or type of malformation (18). Recent studies have also failed to find an association between ovulation induction with clomiphene and neural tube defects (19,20,21,22,23,24 and 25) or any defects (19,23). Congenital malformations reported in patients who received clomiphene before conception include the following (8,9,26,27,28,29,30,31,32,33,34,35,36,37,38,39 and 40): Hydatidiform mole Retinal aplasia Syndactyly Clubfoot Pigmentation defects Microcephaly Congenital heart defects Cleft lip/palate Down's syndrome Ovarian dysplasia Hypospadias Polydactyly Hemangioma Anencephaly Persistent hyperplastic primary vitreous A 1996 prospective study examined the possible relationship between clomiphene and spontaneous abortions (41). The outcomes of 1,744 clomiphene-induced pregnancies were compared with the outcomes of 3,245 spontaneous pregnancies. The incidence of spontaneous abortion (clinical and p