שאלה אחרת

THIORIDAZINE , תרופה נוגדת פסיכוזה, ישנה, "חלשה" יחסית , פוטנטיות נמוכה, אשר מאופיינת בחסימת דופאמין, חסימת היסטמין, חסימת אצטיל כולין ועוד..
השפעה מרגיעה ונוגדת פסיכוזה.
יש תופעות לוואי רבות.
How Drug Causes Side Effects
• By blocking dopamine 2 receptors in the
striatum, it can cause motor side effects
• By blocking dopamine 2 receptors in the
pituitary, it can cause elevations in
prolactin
• By blocking dopamine 2 receptors
excessively in the mesocortical and
mesolimbic dopamine pathways, especially
at high doses, it can cause worsening ofnegative and cognitive symptoms
(neuroleptic-induced deficit syndrome)
• Anticholinergic actions may cause
sedation, blurred vision, constipation, dry
mouth
• Antihistaminic actions may cause sedation,
weight gain
• By blocking alpha 1 adrenergic receptors, it
can cause dizziness, sedation, and
hypotension
• Mechanism of weight gain and any
possible increased incidence of diabetes or
dyslipidemia with conventional
antipsychotics is unknown
] Mechanism of potentially dangerous QTc
prolongation may be related to actions at
ion channels
Notable Side Effects
] Neuroleptic-induced deficit syndrome
] Akathisia
] Priapism
] Extrapyramidal symptoms, Parkinsonism,
tardive dyskinesia
] Galactorrhea, amenorrhea
] Pigmentary retinopathy at high doses
• Dizziness, sedation
• Dry mouth, constipation, blurred vision
• Decreased sweating
• Sexual dysfunction
• Hypotension
• Weight gain